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Table 4 Expression of markers of cell types in cerebrospinal fluid cells and peripheral blood mononuclear cells

From: Cellular sources of dysregulated cytokines in relapsing-remitting multiple sclerosis

  

RRMS relapse

NIND

RRMS relapse vs NIND

 

Mean CT

N

Median (IQR)

CSF/PBMC p-value

N

Median (IQR)

CSF/PBMC p-value

p-value

q-value

CD3d PBMC NR

31.1

15

0.06 (0.04 to 0.08)

 

10

0.05 (0.04 to 0.07)

 

0.47

0.26

CD3d CSF NR

35.6

13

0.10 (0.08 to 0.23)

 

10

0.06 (0.02 to 0.15)

 

0.07

0.09

CD3d CSF/PBMC Ratio

 

11

2.37 (1.30 to 3.67)

0.01

10

1.12 (0.42 to 3.07)

0.39

0.23

0.17

CD14 PBMC NR

30.1

15

0.33 (0.27 to 0.38)

 

10

0.33 (0.29 to 0.49)

 

0.38

0.23

CD14 CSF NR

34.9

13

0.38 (0.07 to 0.52)

 

10

1.52 (0.94 to 2.40)

 

0.0004

0.01

CD14 CSF/PBMC Ratio

 

11

1.39 (0.30 to 2.15)

0.42

10

4.01 (3.54 to 5.16)

0.01

0.003

0.02

CD19 PBMC NR

36.1

15

0.14 (0.09 to 0.23)

 

10

0.08 (0.05 to 0.16)

 

0.05

0.09

CD19 CSF NR

37.1

13

0.00 (0.00 to 0.35)

 

10

0.00 (0.00 to 0.00)

 

0.03

0.09

CD19 CSF/PBMC Ratio

 

11

0.00 (0.00 to 0.89)

 

10

0.00 (0.00 to 0.00)

 

0.04

0.09

CD56 PBMC NR

34.9

15

0.15 (0.09 to 0.23)

 

10

0.16 (0.07 to 0.32)

 

0.96

0.43

CD56 CSF NR

37.8

13

0.00 (0.00 to 0.03)

 

10

0.00 (0.00 to 0.00)

 

0.11

0.10

CD56 CSF/PBMC Ratio

 

11

0.00 (0.00 to 0.00)

 

10

0.00 (0.00 to 0.00)

 

0.17

0.14

  1. Gene expression data are shown as normalization ratio (NR). Mean cycle threshold (CT) is shown for each target. CSF/PBMC ratio represent fold change in expression between CSF cells and PBMCs. CSF/PBMC p-values represents Wilcoxon signed rank test results, and tests were only conducted if median CSF NR was >0. All other p-values represent Mann–Whitney tests for difference between groups, and q-values represent false discovery rate corrected p-values. Significant test-values are in bold. RRMS relapse: Relapsing-remitting multiple sclerosis patients in relapse. NIND: Non-inflammatory neurological disease. PBMC: Peripheral blood mononuclear cell. CSF: Cerebrospinal fluid. IQR: Interquartile range.
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Journal of Neuroinflammation

ISSN: 1742-2094