Figure 1
From: Complement is dispensable for neurodegeneration in Niemann-Pick disease type C
C1q and complement component expression is increasingly elevated with age in NPC disease. (A) Compilation of analyses from three independent cerebellar array datasets accessible through the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database: a, GSE36119; b, GSE5944; and c, GSE20450. The differential gene expression of components of the complement cascade for Npc1 -/- mice compared to wild-type, Npc1 +/- or Npc1 +/+, mice are shown at two ages. (B) An outline of the initial components of the complement cascade (genes are in bold) showing factors in the pathway that have been identified as elevated in at least one array dataset. (C) Representative in situ signal of C1qa mRNA probe hybridized to thalamic region of P60 wild-type, Npc1 -/-, and C1qa -/-; Npc1 -/- mice. Scale bars are 100μm.