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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Immunoglobulin G (IgG) attenuates neuroinflammation and improves neurobehavioral recovery after cervical spinal cord injury

Figure 5

IgG reduces scar and cavity formation and preserves neural tissue. (A) The distribution of scar and cavity area over 4000 μm of the injured spinal cords of sham (n = 4), saline (n = 7), and IgG (n = 7) animals was calculated at 6 weeks following injury. There was a treatment effect in the area of cavitation and scar in IgG-treated animals (two-way ANOVA, P = 0.013). IgG-treated animals had significantly less scar and cavity area at 600 μm (P = 0.012) and 720 μm (P = 0.042). (B) Preserved tissue (remaining grey and white matter) in injured spinal cords was calculated. There was an overall treatment effect in the amount of tissue sparing in IgG-treated animals (two-way ANOVA, P = 0.015). IgG-treated animals had significantly more preserved tissue compared to saline-treated animals at a distance of 600 μm (P = 0.002), 720 μm (P = 0.017), and 840 μm (P = 0.044) rostral to the injury epicenter. (C) Representative H&E/LFB images are shown. Error bars represent SEM.

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