Hypoglycemia induces microglial activation in the brain. Light microscopy images show microglial activation after hypoglycemia. In the sham operated animal, CD11b-positive cells are negligible in all brain areas (Sham). However, a substantial degree of microglial activation is detected in the hippocampus (Subiculum, CA1, and dentate gyrus (DG)), striatum (ST) and cerebral cortex (CTX) 5 days after hypoglycemia. This histological finding suggests that the inflammatory response is involved in hypoglycemia-induced neuronal injury. Scale bar = 200 μm.