Minocycline reduces motor hyperactivity and cognitive impairment induced by hypoglycemia. Six weeks after induction of hypoglycemia, rats were subjected to a 3-day novel open field test followed by the Barnes maze test. Four groups of animals were divided for behavioral testing as follows: sham + Vehicle; sham + minocycline (MINO); hypoglycemia + Vehicle; and hypoglycemia + minocycline (MINO) groups. Minocycline reduced overall hyperactivity induced by hypoglycemia in both horizontal and vertical dimensions as shown in total path length (A) and rearing events (B). Minocycline also improved the performance of rats with hypoglycemia in the Barnes maze test over 5 days of training (C). *P < 0.05, #
P < 0.01 comparing HG + Vehicle and HG + MINO groups.