MAPC treatment changes macrophage/microglia
phenotype after TBI. Graph of the ratio of anti-inflammatory microglia versus proinflammatory microglia as determined by flow cytometry. Measurement of brain CD86+ M1 and CD206+ M2 macrophages was completed after cortical injury in mice at 24, 48, 72, and 120 hours after CCI injury (n = 6/group). There were significant increases in the ratio of M2 versus M1 mean fluorescence intensity between the CCI plus MAPC versus CCI alone at 24 (P ≤0.05), 48 (P ≤0.01) and 120 hours (P ≤0.01) after injury* represents P <0.05 and ** represents P <0.01. CCI, controlled cortical impact; MAPC, multipotent adult progenitor cell; TBI, traumatic brain injury.