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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Expression of myeloid differentiation factor 88 in neurons is not requisite for the induction of sickness behavior by interleukin-1β

Figure 1

MyD88 is required for sickness behavior in response to central IL-1β injection. WT and MyD88KO mice received i.c.v. injections of IL-1β (10 ng) or TNF (500 ng) 1 h before the onset of the dark cycle (n = 5 to 6/group). (a, e) Cumulative food intake. (b, f) Overnight change in body weight. (c, g) Hourly locomotor activity. (d, h) Cumulative locomotor activity over 8 h post injection. All data are represented as mean ± s.e.m. In some cases, error bars are too small to see. KO, MyD88KO; ZT, Zeitgeber Time. ***, P <0.001; **, P <0.01; *, P <0.05 as measured by two-way ANOVA with Bonferroni post-test.

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