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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Expression of myeloid differentiation factor 88 in neurons is not requisite for the induction of sickness behavior by interleukin-1β

Figure 5

MyD88 expression in the CNS is not required for IL-1β-induced sickness behavior. WT and MyD88ΔCNS mice received i.c.v. injections of IL-1β (10 ng) 1 h before the onset of the dark cycle (n = 4 to 9/group). (a) Cumulative food intake. (b) Overnight change in BW. (c) Hourly locomotor activity. (d) Cumulative locomotor activity over 8 h post injection. All data are represented as the mean ± s.e.m. In some cases error bars are too small to see. Lox, MyD88Lox/lox; ΔCNS, MyD88ΔCNS; ZT, Zeitgeber Time. ***, P <0.001; **, P <0.01; *, P <0.05 as measured by two-way ANOVA with Bonferroni post-test.

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