Figure 6
MyD88 expression in the CNS is not required for IL-1β-induced suppression of refeeding. WT and MyD88ΔCNS mice were fasted overnight for 12 h and then received i.c.v. injections of IL-1β (10 ng) 15 minutes prior to food being returned to the cages (n = 4 to 5/group). (a) Cumulative food intake 0 to 5 h. (b) Cumulative food intake at 2 h. (c) Cumulative food intake 0 to 36 h. (d) Cumulative food intake at 24 h. All data are represented as the mean ± s.e.m. ΔCNS, MyD88ΔCNS. ** ; P <0.01, * ; P <0.05 as measured by two-way ANOVA with Bonferroni post-test.