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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Pharmacokinetics and modeling of immune cell trafficking: quantifying differential influences of target tissues versus lymphocytes in SJL and lipopolysaccharide-treated mice

Figure 2

Comparison between CD-1 males and SJL females of clearance from blood and uptake by immune tissues of 131 I-lymphocytes. Upper left panel shows clearance of 131I-lymphocytes from the circulation. The half-time clearance for CD-1 mice was 171 min, but clearance was not measurable for SJL mice. Upper right panel shows that uptake of 131I-lymphocytes into cervical nodes was high in both SJL and CD-1 mice and did not differ between the strains. Lower left panel showed high uptake of 131I-lymphocytes by axillary nodes was similar between SJL and CD-1 mice except for the 30 min time point when CD-1 mice had a higher uptake. Lower right panel shows that spleen uptake was the highest of all the tissues examined and that uptake by CD-1 mice was about 2 to 3 times higher than by SJL mice.

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Journal of Neuroinflammation

ISSN: 1742-2094