Figure 5

Comparison of ¹³¹ I-lymphocyte tissue uptake in SJL female and CD-1 male mice. A 2 × 2 design was used where lymphocytes from the cervical lymph nodes of SJL mice were injected into either CD-1 or SJL mice and lymphocytes from the cervical lymph nodes of CD-1 mice were injected into SJL or CD-1 mice. Upper right panel shows that SJL mice tended to have higher levels in the circulation of cells, regardless of source. Consistent with this, Cells (lymphocytes) accounted for only 10% of statistical variance, whereas the Mouse (tissues of uptake) accounted for 46%. Upper right panel shows higher uptake of Cells from either source into brain; statistical analysis showed that Cells accounted for 31% of variance. Lower left panel shows that Cells accounted for 40% of the statistical variance whereas Mouse accounted for 14%. Lower right panel shows uptake by cervical lymph nodes; there were not statistical differences among the four groups.