C-[R]-PK11195 brain positron emission
tomography scan. PK11195 brain PET scan showing PK11195 brain distribution in a child (upper row) and healthy normal adult (lower row). The overall brain PK11195 uptake is relatively low, suggested by much lower cortical PK11195 uptake compared to subcortical structures, and the pattern of PK11195 distribution is largely similar in both children and adults, although PK11195 uptake appears to be visually slightly higher in adults, particularly in the thalamus and midbrain. Highest PK11195 uptake is noted in the pituitary gland and midbrain, followed by thalamus, basal ganglia, occipital cortex, hippocampus and cerebellum. The rest of the cerebral cortex is showing low PK11195 uptake with minimal uptake in white matter. BG: basal ganglia; MB: midbrain; Cer: cerebellum; Cg: cingulum; F: frontal cortex; Hip: hippocampus; P: parietal cortex; Pit: pituitary gland; T: temporal cortex; Th: thalamus; R: right side; L: left side.