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Table 2 Binding potential values of 11 C-[R]-PK11195 in various brain regions

From: Evaluation of age-related changes in translocator protein (TSPO) in human brain using 11C-[R]-PK11195 PET

  

Binding potential (mean ±SD (95% CI))

 

Side

Adults (n = 15)

Children (n = 10)

P

Pituitary gland

 

0.62 ±0.18 (0.49 to 0.75)

0.61 ±0.19 (0.15 to 1.07)*

0.95

Midbrain

 

0.45 ±0.09 (0.38 to 0.48)

0.41 ±0.08 (0.40 to 0.48)

0.09

Thalamus

Left

0.35 ±0.04 (0.33 to 0.37)

0.28 ±0.13 (0.19 to 0.37)

0.08

 

Right

0.34 ±0.07 (0.30 to 0.37)

0.29 ±0.12 (0.21 to 0.37)

0.20

Lentiform nucleus

Left

0.20 ±0.05 (0.17 to 0.23)

0.19 ±0.07 (0.14 to 0.24)

0.63

 

Right

0.15 ±0.05 (0.12 to 0.18)

0.15 ±0.07 (0.09 to 0.21)

0.92

Caudate

Left

0.10 ±0.05 (0.07 to 0.13)

0.08 ±0.06 (0.03 to 0.13)

0.45

 

Right

0.09 ±0.04 (0.07 to 0.12)

0.08 ±0.05 (0.01 to 0.14)

0.46

Hippocampus

Left

0.11 ±0.04 (0.07 to 0.14)

0.07 ±0.04 (0.03 to 0.12)

0.20

 

Right

0.10 ±0.06 (0.06 to 0.14)

0.10 ±0.06 (0.04 to 0.15)

0.83

Cerebellum

Left

0.10 ±0.04 (0.07 to 0.12)

0.08 ±0.03 (0.05 to 0.11)

0.45

 

Right

0.09 ±0.04 (0.07 to 0.11)

0.07 ±0.03 (0.05 to 0.10)

0.24

Frontal cortex

Left

0.06 ±0.03 (0.04 to 0.07)

0.05 ±0.01 (0.04 to 0.06)

0.47

 

Right

0.05 ±0.03 (0.03 to 0.07)

0.05 ±0.03 (0.03 to 0.07)

0.85

Parietal cortex

Left

0.04 ±0.03 (0.02 to 0.05)

0.03 ±0.02 (0.01 to 0.04)

0.64

 

Right

0.04 ±0.01 (0.03 to 0.05)

0.04 ±0.03 (0.02 to 0.06)

0.53

Temporal cortex

Left

0.05 ±0.03 (0.03 to 0.07)

0.05 ±0.02 (0.03 to 0.07)

0.85

 

Right

0.05 ±0.02 (0.03 to 0.06)

0.02 ±0.02 (0.03 to 0.07)

0.91

Occipital cortex

Left

0.11 ±0.05 (0.08 to 0.14)

0.11 ±0.04 (0.08 to 0.13)

0.79

 

Right

0.12 ±0.03 (0.10 to 0.14)

0.12 ±0.02 (0.10 to 0.13)

0.88

  1. *Pituitary binding potential values available in three children only, as it could not be estimated in seven children because of an inability to reliably delineate the pituitary from the surrounding lymphoid tissue/circular venous plexus in these children. CI confidence intervals; SD standard deviation.