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Table 1 Association between promoter variants with TNF-α promoter and ischemic stroke

From: Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke

ID SNP rs ID Function Population MAF P allele MM Mm mm Crude Crude ORs (95%CI) Adjusted Adjusted ORs (95%CI)
  (M > m)      n, (%) n, (%) n, (%) P dominant MM vs.Mm + mm(ref) P dominant MM vs.Mm + mm(ref)
First study             
1 rs1799964 Promoter Control (n = 1,027) 0.231 0.01 599 (58.3) 381 (37.1) 47 (4.6) 0.025 1.21 (1.02-1.42) 0.015 1.25 (1.04-1.49)
  (T > C)   IS (n = 1,388) 0.201   872 (62.8) 475 (34.2) 41 (3.0)     
2 rs1800629 Promoter Control (n = 1,027) 0.071 0.026 886 (86.3) 136 (13.2) 5 (0.5) 0.034 1.30 (1.02-1.67) 0.038 1.34 (1.02-1.77)
  (G > A)   IS (n = 1,388) 0.055   1,237 (89.1) 148 (10.7) 3 (0.2)     
3 rs1799724 Promoter Control (n = 1,027) 0.173 0.45 700 (68.2) 299 (29.1) 28 (2.7) 0.15 0.88 (0.74-1.05) 0.81 0.98 (0.81-1.18)
  (C > T)   IS (n = 1,388) 0.181   907 (65.3) 459 (33.1) 22 (1.6)     
4 rs361525 Promoter Control (n = 1,027) 0.03   968 (94.3) 56 (5.5) 3 (0.2) 0.96 1.01 (0.71-1.43) 0.103 1.41 (0.93-2.13)
  (A > G)   IS (n = 1,388) 0.029 0.781 1,309(94.3) 78 (5.6) 1 (0.1)     
Second study    
1 rs1799964 Promoter Control (n = 821) 0.176 0.912 557 (67.8) 239 (29.1) 25 (3.1) 0.96 0.99 (0.81-1.21) 0.87 1.02 (0.79-1.33)
  (T > C)   IS (n = 961) 0.177   650 (67.6) 281 (29.2) 30 (3.2)     
2 rs1800629 Promoter Control (n = 821) 0.07 0.011 710 (86.5) 107 (13) 4 (0.5) 0.011 1.46 (1.09-1.96) 0.016 1.56 (1.09-2.23)
  (G > A)   IS (n = 961) 0.05   868 (90.3) 90 (9.4) 3 (0.3)     
3 rs1799724 Promoter Control (n = 821) 0.196 0.506 529 (64.4) 262 (31.9) 30 (3.7) 0.29 1.11 (0.91-1.35) 0.052 0.79 (0.62-1.00)
  (C > T)   IS (n = 961) 0.187   642 (66.8) 278 (28.9) 41 (4.3)     
4 rs361525 Promoter Control (n = 821) 0.037 0.974 761 (92.7) 59 (7.2) 1 (0.1) 0.95 0.99 (0.69-1.41) 0.22 0.74 (0.46-1.19)
  (A > G)   IS (n = 961) 0.037   890 (92.6) 71 (7.4) 0 (0)     
  1. IS, ischemic stroke; M, major allele; m, minor allele; MAF, minor allele frequency.
  2. P allele value of allele and Crude odds ratio (95% confidence interval) were determined by a 95% two-sided χ2 test, IS versus controls.
  3. P dominant value and adjusted odds ratio (95% confidence interval) were computed with multivariate unconditional logistic regression analysis by adjusting for gender, age, body mass index, hypertension, diabetes, hyperlipidemia, and smoking status.