Figure 1

Effect of the FXTAS premutation status on the various phenotypes studied. (A) For each phenotype, the mean and standard deviation (SD) (or the percentage) were computed for the control and premutation groups. Various statistical tests were applied and their associated P values were computed according to the type and the distribution of the phenotypes in order to assess the effect of the clinical status. For normally distributed features (age and Fragile X-associated tremor/ataxia syndrome (FXTAS) score), a one-way analysis of variance was used. For the non-normally distributed phenotypes, such as diastolic and systolic blood pressure (DBP and SBP) and hemoglobin A1c (HbA1c) concentrations, a Kruskal–Wallis test was applied using the ranks instead of the raw values. Finally, for binary phenotypes (percentage of smokers and of individuals under treatment), a generalized linear model was applied. (B) Boxplot representing the distribution (median and interquartile range) of the FXTAS scores for control and premutation groups.