Table 1 Serum and CSF mean (± SD) concentrations (pg/mL) of cytokines at A, B and C

A

1.36 ± 1.12 N = 34

0.63 ± 0.06 N = 34

1.20 ± 1.51 N = 34

0.62 ± 0.04 N = 34

1.05 ± 0.91 N = 34

23.98 ± 116.12 N = 34

3.53 ± 4.09 N = 34

3.35 ± 5.02 N = 34

11.81 ± 26.15 N = 34

8.62 ± 3.05 N = 34

B

1.49 ± 1.18 N = 34

0.64 ± 0.12 N = 34

0.95 ± 0.64 N = 34

0.62 ± 0.08 N = 34

1.00 ± 0.08 N = 34

26.86 ± 123.50 N = 34

6.00 ± 7.43 N = 34

3.35 ± 5.10 N = 34

10.96 ± 23.36 N = 34

9.35 ± 3.71 N = 34

C

1.07 ± 0.78 N = 34

0.64 ± 0.12 N = 34

1.16 ± 1.64 N = 34

0.63 ± 0.10 N = 34

1.61 ± 1.51 N = 34

30.19 ± 126.82 N = 34

9.62 ± 7.28 N = 34

3.11 ± 4.60 N = 34

9.54 ± 19.15 N = 34

7.91 ± 2.25 N = 34

Friedman′s statistics

χ2 (2) = 5.009 n.s.

χ2 (2) = 0.857 n.s.

χ2 (2) = 0.364 n.s.

χ2 (2) = 0.286 n.s.

χ2 (2) = 7.013 P = 0.03*

χ2 (2) = 43.304 P <0.001***

χ2 (2) = 49.259 P <0.001***

χ2 (2) = 0.505 n.s.

χ2 (2) = 4.047 n.s.

χ2 (2) = 9.450 P = 0.009**

Wilcoxon signed rank test P -values

AB n.s. AC P = 0.03* BC P = 0.02*

AB P <0.001*** AC P <0.001*** BC n.s.

AB P <0.001** AC P <0.001*** BC P <0.001***

AB n.s. AC P = 0.03* BC n.s.

CSF

IFN-γ

IL-1β

IL-2

IL-4

IL-5

IL-8

IL-10

IL-12

IL-13

TNF

A

0.70 ± 0.29 N = 26

0.63 ± 0.10 N = 25

0.63 ± 0.54 N = 25

0.61 ± 0.00 N = 25

0.61 ± 0.00 N = 25

30.40 ± 8.80 N = 25

0.76 ± 0.22 N = 25

0.64 ± 0.13 N = 25

0.61 ± 0.00 N = 25

0.67 ± 0.14 N = 25

B

1.08 ± 0.97 N = 26

0.84 ± 0.47 N = 25

4.74 ± 10.77 N = 25

0.62 ± 0.05 N = 25

1.31 ± 1.87 N = 25

880.68 ± 1975.95 N = 25

6.91 ± 14.69 N = 25

1.54 ± 2.55 N = 25

3.02 ± 5.64 N = 25

2.76 ± 5.07 N = 25

C

0.93 ± 0.80 N = 26

0.79 ± 0.35 N = 25

3.38 ± 6.33 N = 25

0.61 ± 0.00 N = 25

0.99 ± 0.79 N = 25

543.20 ± 964.20 N = 25

5.15 ± 9.23 N = 25

1.21 ± 1.91 N = 25

3.26 ± 4.36 N = 25

1.77 ± 2.32 N = 25

Friedman′s statistics

χ2(2) = 3.150 n.s.

χ2(2) = 4.839 n.s.

χ2(2) = 19.316 P <0.001***

χ2 (2) = 4.00 n.s.

χ2 (2) = 10.042 P = 0.007**

χ2 (2) = 38.000 P <0.001***

χ2 (2) = 27.758 P <0.001***

χ2 (2) = 5.892 n.s.

χ2 (2) = 23.343 P <0.001***

χ2 (2) = 17.956 P <0.001***

Wilcoxon signed rank test P -values

AB P = 0.001*** AC P <0.001*** BC n.s.

AB n.s. AC P = 0.002 ** BC n.s.

AB P <0.001*** AC P <0.001*** BC n.s.

AB P <0.001*** AC P <0.001*** BC n.s.

AB P <0.001*** AC P = 0.001*** BC n.s.

AB P <0.001*** AC P <0.001*** BC n.s.