Figure 4

Histological analysis of spinal cord and brain sections after treatment with EAE. Spinal cords and brains from COAM- (n = 2) and saline-treated EAE animals (n = 2) were isolated during acute disease (day 17 after immunization) and fixed in 4% formol. Four micron thick paraffin sections were stained with H & E. Scale bars represent 100 μm. In the control sections, black arrows indicate prominent leukocyte infiltrations and at the surface perimeningeal leukocytes are visible. After treatment with COAM the numbers and sizes of these infiltrations were reduced. COAM, chlorite-oxidized oxyamylose; EAE, experimental autoimmune encephalomyelitis.