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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood–brain barrier through paracellular transmigration and ERK activation

Figure 1

Distribution of CD11c + dendritic cells in d16 experimental autoimmune encephalomyelitis mice. Ex vivo near-infrared fluorescence imaging of d16 experimental autoimmune encephalomyelitis (EAE) mice showing the distribution of CD11c+ dendritic cells (DCs) in the context of CD3+ T cells and myelin basic protein (MBP). (A) Anti-CD11c antibody only (green) signal from DCs in a mouse with severe degree of EAE. (B) Mouse with moderate EAE score shows signal from both CD11c+ DCs (green) and CD3+ T cells (red) along the thoracic and lumbar spine. (C) Mouse exhibiting mild EAE shows a high degree of co-localization between CD11c+ DCs and MBP signal.

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Journal of Neuroinflammation

ISSN: 1742-2094