Figure 4From: Exacerbation of experimental autoimmune encephalomyelitis in prion protein (PrPc)-null mice: evidence for a critical role of the central nervous system CD4+ T cells from Prnp -/- and Prnp +/+ EAE-induced mice respond similarly to MOG 35-55 . (A) In vitro proliferation of purified CD4+ T cells from 3 Prnp -/- and 3 Prnp +/+ primed mice tested individually. Thymidine incorporation was measured after 92 hours of culture. (B) and (C) concentrations of IFN-γ and IL-17 in supernatants collected at 48 hour of culture of MOG-primed CD4+ T cells in vitro reactivated with APC and MOG peptide. (D) anti-PrP antibodies titrated by solid phase ELISA in individual sera of EAE-induced mice collected at 22 dpi.Back to article page