Exacerbation of experimental autoimmune encephalomyelitis in prion protein (PrPc)-null mice: evidence for a critical role of the central nervous system

Table 2 Hematopoietic reconstitution of irradiated CD45.1⁺ mice by CD45.2⁺ BM

[*Prnp* ^-/- > Prnp^+/+]	CD19+		CD4+		CD8+
	CD45.1+	CD45.2+	CD45.1+	CD45.2+	CD45.1+	CD45.2+
#1	0.1	65.04	2.34	16.95	1.64	8.53
#2	0.14	57.56	2.86	18.34	2.28	11.45
#3	0.07	60.94	1.83	19.04	2.45	10.21
#4	0.04	64.02	2.31	17.24	1.79	8.86
#5	0.08	59.17	3.33	19.93	1.8	9.82
#6	0.03	65.27	2.86	17.31	1.57	8.41
#7	0.09	58.02	4.23	19.54	2.84	10.18
[ *Prnp* ^+/+ *> Prnp* ^-/- ]	CD19+		CD4+		CD8+
	CD45.1+	CD45.2+	CD45.1+	CD45.2+	CD45.1+	CD45.2+
#1	0.05	52.13	3.41	20.11	2.98	10.61
#2	0.09	56.37	3.59	21.66	3.1	10.46
#3	0.12	60.21	3.97	19.15	3.26	9.62
#4	0.15	59.91	3.89	18.88	3.28	9.83
#5	0.11	56.15	4.24	20.15	3.32	9.68
#6	0.2	60.52	3.27	17.23	2.59	8.88
#7	0.15	47.91	3.58	18.44	3.18	10.02
[ *Prnp* ^+/+ *> Prnp* ^+/+ ]	CD19+		CD4+		CD8+
	CD45.1+	CD45.2+	CD45.1+	CD45.2+	CD45.1+	CD45.2+
#1	0.08	65.16	2.24	18.17	1.5	9.07
#2	0.08	67.21	1.92	17.3	1.35	8.29
#3	0.04	63.49	1.3	16.96	0.7	8.88
#4	0.02	69.12	2.52	15.95	1.29	7.25
[ *Prnp* ^-/- *> Prnp* ^-/- ]	CD19+		CD4+		CD8+
	CD45.1+	CD45.2+	CD45.1+	CD45.2+	CD45.1+	CD45.2+
#1	0.12	52.03	5.18	22.91	3.46	11.66
#2	0.09	54.22	3.93	19,76	3.54	12.3
#3	0.12	57.48	4.3	20.02	2.82	11.06

PBMC samples were phenotyped 10 weeks post-transfer by cell-surface staining. Lymphocyte percentages were assessed by flow cytometry

ISSN: 1742-2094