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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5

Figure 3

Cortical capillary morphology is not changed in Tat-transgenic (Tat-tg) mice. (A) Representative image of three-dimensional stacks of cortical tissue capillaries (10x magnification) used for skeletonization with the filament tool in Amira software. (B) Schematic of vessel branching used for quantification of morphological features in the skeletonized images. (C) The number of nodes and segments in wild type (WT) and Tat-tg mice. (D) Mean length of segments. (E) Mean radius of vessels. (F) Total volume of vessels in one 3-dimensional image stack (500 μm x 500 μm x 100 μm). (C-F) Data extracted from same animals, seven WT and seven Tat-tg. Data represent mean ± SEM. Comparison of cortical capillary parameters from WT and Tat-tg failed to reach statistical significance

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