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Table 1 Physiological parameters in mice before and after exposure to 6% CO 2

From: Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5

   MAP, mm Hg Arterial blood pH PaCO2, mm Hg PaO2, mm Hg
Group (N) Exposure to CO2 Before After Before After Before Before
WT (4) 5 min 74.72 ± 4.48 75.52 ± 3.85 7.36 ± 0.02 7.19 ± 0.04 36.33 ± 1.25 96.5 ± 2.65
Tat-tg (7) 5 min 72.86 ± 3.45 71.94 ± 3.66 7.34 ± 0.01 7.19 ± 0.03 37.68 ± 1.79 100.88 ± 2.65
WT (15) 30 sec 73.29 ± 1.67 71.19 ± 1.65 7.35 ± 0.01 7.27 ± 0.02 35.21 ± 0.65 103.7 ± 1.84
Tat-tg (16) 30 sec 75.63 ± 1.74 76.09 ± 1.79 7.35 ± 0.01 7.28 ± 0.01 35.69 ± 1.19 102.98 ± 2.65
Tat+BH4 (3) 30 sec 73.2 ± 2.93 73.0 ± 2.48 7.34 ± 0.02 7.28 ± 0.01 36.9 ± 2.25 103.36 ± 10.7
Tat+PDEi (12) 30 sec 75.74 ± 2.39 74.72 ± 2.01 7.36 ± 0.03 7.25 ± 0.03 35.52 ± 0.83 104.1 ± 1.93
Tat+Combo (3) 30 sec 75.03 ± 5.87 73.43 ± 4.72 7.35 ± 0.02 7.26 ± 0.02 37.77 ± 1.27 108.7 ± 5.27
WT+Combo (3) 30 sec 74.2 ± 1.01 71.27 ± 0.74 7.34 ± 0.01 7.21 ± 0.04 38.57 ± 2.65 104.57 ± 10.19
Tat-tg+Vehicle (4) 30 sec 73.3 ± 0.87 74.58 ± 1.04 7.36 ± 0.02 7.28 ± 0.01 34.90 ± 1.7 101.45 ± 1.96
Tat-tg UI (6) 30 sec 81.35 ± 2.69 78.4 ± 2.34 7.35 ± 0.03 7.27 ± 0.02 40.55 ± 4.54 99.73 ± 1.94
Tat-injected (4) 30 sec 79.95 ± 4.66 78.23 ± 4.70 7.38 ± 0.02 7.25 ± 0.03 37.15 ± 1.67 101.25 ± 1.40
gp140-injected (4) 30 sec 74.33 ± 4.70 72.78 ± 4.42 7.36 ± 0.01 7.26 ± 0.01 36.03 ± 1.56 106.05 ± 5.42
  1. PDEi, gisadenafil; Combo, combined PDEi and BH4; MAP, mean arterial pressure; PaCO2, partial arterial pressure of CO2;
  2. PaO2, partial arterial pressure of O2; UI, Uninduced. Data shown as mean ± SEM.