Skip to main content

Table 1 Physiological parameters in mice before and after exposure to 6% CO 2

From: Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5

  

MAP, mm Hg

Arterial blood pH

PaCO2, mm Hg

PaO2, mm Hg

Group (N)

Exposure to CO2

Before

After

Before

After

Before

Before

WT (4)

5 min

74.72 ± 4.48

75.52 ± 3.85

7.36 ± 0.02

7.19 ± 0.04

36.33 ± 1.25

96.5 ± 2.65

Tat-tg (7)

5 min

72.86 ± 3.45

71.94 ± 3.66

7.34 ± 0.01

7.19 ± 0.03

37.68 ± 1.79

100.88 ± 2.65

WT (15)

30 sec

73.29 ± 1.67

71.19 ± 1.65

7.35 ± 0.01

7.27 ± 0.02

35.21 ± 0.65

103.7 ± 1.84

Tat-tg (16)

30 sec

75.63 ± 1.74

76.09 ± 1.79

7.35 ± 0.01

7.28 ± 0.01

35.69 ± 1.19

102.98 ± 2.65

Tat+BH4 (3)

30 sec

73.2 ± 2.93

73.0 ± 2.48

7.34 ± 0.02

7.28 ± 0.01

36.9 ± 2.25

103.36 ± 10.7

Tat+PDEi (12)

30 sec

75.74 ± 2.39

74.72 ± 2.01

7.36 ± 0.03

7.25 ± 0.03

35.52 ± 0.83

104.1 ± 1.93

Tat+Combo (3)

30 sec

75.03 ± 5.87

73.43 ± 4.72

7.35 ± 0.02

7.26 ± 0.02

37.77 ± 1.27

108.7 ± 5.27

WT+Combo (3)

30 sec

74.2 ± 1.01

71.27 ± 0.74

7.34 ± 0.01

7.21 ± 0.04

38.57 ± 2.65

104.57 ± 10.19

Tat-tg+Vehicle (4)

30 sec

73.3 ± 0.87

74.58 ± 1.04

7.36 ± 0.02

7.28 ± 0.01

34.90 ± 1.7

101.45 ± 1.96

Tat-tg UI (6)

30 sec

81.35 ± 2.69

78.4 ± 2.34

7.35 ± 0.03

7.27 ± 0.02

40.55 ± 4.54

99.73 ± 1.94

Tat-injected (4)

30 sec

79.95 ± 4.66

78.23 ± 4.70

7.38 ± 0.02

7.25 ± 0.03

37.15 ± 1.67

101.25 ± 1.40

gp140-injected (4)

30 sec

74.33 ± 4.70

72.78 ± 4.42

7.36 ± 0.01

7.26 ± 0.01

36.03 ± 1.56

106.05 ± 5.42

  1. PDEi, gisadenafil; Combo, combined PDEi and BH4; MAP, mean arterial pressure; PaCO2, partial arterial pressure of CO2;
  2. PaO2, partial arterial pressure of O2; UI, Uninduced. Data shown as mean ± SEM.