|  | MAP, mm Hg | Arterial blood pH | PaCO2, mm Hg | PaO2, mm Hg | ||
---|---|---|---|---|---|---|---|
Group (N) | Exposure to CO2 | Before | After | Before | After | Before | Before |
WT (4) | 5 min | 74.72 ± 4.48 | 75.52 ± 3.85 | 7.36 ± 0.02 | 7.19 ± 0.04 | 36.33 ± 1.25 | 96.5 ± 2.65 |
Tat-tg (7) | 5 min | 72.86 ± 3.45 | 71.94 ± 3.66 | 7.34 ± 0.01 | 7.19 ± 0.03 | 37.68 ± 1.79 | 100.88 ± 2.65 |
WT (15) | 30 sec | 73.29 ± 1.67 | 71.19 ± 1.65 | 7.35 ± 0.01 | 7.27 ± 0.02 | 35.21 ± 0.65 | 103.7 ± 1.84 |
Tat-tg (16) | 30 sec | 75.63 ± 1.74 | 76.09 ± 1.79 | 7.35 ± 0.01 | 7.28 ± 0.01 | 35.69 ± 1.19 | 102.98 ± 2.65 |
Tat+BH4 (3) | 30 sec | 73.2 ± 2.93 | 73.0 ± 2.48 | 7.34 ± 0.02 | 7.28 ± 0.01 | 36.9 ± 2.25 | 103.36 ± 10.7 |
Tat+PDEi (12) | 30 sec | 75.74 ± 2.39 | 74.72 ± 2.01 | 7.36 ± 0.03 | 7.25 ± 0.03 | 35.52 ± 0.83 | 104.1 ± 1.93 |
Tat+Combo (3) | 30 sec | 75.03 ± 5.87 | 73.43 ± 4.72 | 7.35 ± 0.02 | 7.26 ± 0.02 | 37.77 ± 1.27 | 108.7 ± 5.27 |
WT+Combo (3) | 30 sec | 74.2 ± 1.01 | 71.27 ± 0.74 | 7.34 ± 0.01 | 7.21 ± 0.04 | 38.57 ± 2.65 | 104.57 ± 10.19 |
Tat-tg+Vehicle (4) | 30 sec | 73.3 ± 0.87 | 74.58 ± 1.04 | 7.36 ± 0.02 | 7.28 ± 0.01 | 34.90 ± 1.7 | 101.45 ± 1.96 |
Tat-tg UI (6) | 30 sec | 81.35 ± 2.69 | 78.4 ± 2.34 | 7.35 ± 0.03 | 7.27 ± 0.02 | 40.55 ± 4.54 | 99.73 ± 1.94 |
Tat-injected (4) | 30 sec | 79.95 ± 4.66 | 78.23 ± 4.70 | 7.38 ± 0.02 | 7.25 ± 0.03 | 37.15 ± 1.67 | 101.25 ± 1.40 |
gp140-injected (4) | 30 sec | 74.33 ± 4.70 | 72.78 ± 4.42 | 7.36 ± 0.01 | 7.26 ± 0.01 | 36.03 ± 1.56 | 106.05 ± 5.42 |