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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord

Figure 2

Local inflammatory responses of the tongue after CFA injection. Shown are the representative histological staining of the tongue before (A, D, G, and Ga), on day 8 (B, E, H, and Ha), and day 15 (C, F, I, and Ia) after CFA injection. A to C, Evans Blue staining; D to I, HE staining; G to I are enlarged photographs taken from the rectangle area in D to F, respectively. CFA injection into the tongue resulted in dramatic plasma extravasation and inflammatory cell infiltration on day 8 but not on day 15. Arrows in Ga-Ia indicate lymphocytes infiltrated into the tongue. Scale bars: 1 mm in A to F, 200 μm in G to I, 20 μm in Ga to Ia.

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