Figure 2From: Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord Local inflammatory responses of the tongue after CFA injection. Shown are the representative histological staining of the tongue before (A, D, G, and Ga), on day 8 (B, E, H, and Ha), and day 15 (C, F, I, and Ia) after CFA injection. A to C, Evans Blue staining; D to I, HE staining; G to I are enlarged photographs taken from the rectangle area in D to F, respectively. CFA injection into the tongue resulted in dramatic plasma extravasation and inflammatory cell infiltration on day 8 but not on day 15. Arrows in Ga-Ia indicate lymphocytes infiltrated into the tongue. Scale bars: 1 mm in A to F, 200 μm in G to I, 20 μm in Ga to Ia.Back to article page