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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord

Figure 5

Quantification of the time course of pERK expression in the Vc and C1-C2 after saline and CFA injection into the tongue. Shown is the mean number of pERK-IR cells triggered by noxious mechanical stimulation of the tongue in ipsilateral (A) and contralateral (B) Vc and C1-C2 on days 3, 8, and 15 after saline and CFA treatment and in naive rats. (C) Normalized amount of pERK protein expression on day 8 after saline or CFA injection into the tongue. β-actin was used as a loading control. (D and E) Quantification of the time course of pERK expression in Vc and C1-C2 neurons after CFA injection into the tongue and in naive rats without noxious stimulation. Shown is the mean number of pERK-IR cells in ipsilateral (D) and contralateral (E) Vc and C1-C2 on days 3, 8, and 15 after CFA injection. CFA injection into the tongue initiated a much stronger pERK expression in Vc and C1-C2 than the control group, regardless of the presence of noxious stimulation. n = 5 in each group. Error bars indicate SEM.

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