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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord

Figure 6

Effects of continuous i.t. administration of the MEK inhibitor, PD98059, on the development of mechanical allodynia and heat hyperalgesia and CFA-induced ERK phosphorylation. Time course of changes in MHWT (A) and HHWT (B) in both vehicle- and PD98059-treated groups. n = 5 to 6 in each group. (C) The mean number of noxious stimuli-evoked pERK-IR cells in the ipsilateral and contralateral Vc and C1-C2 on day 8 after CFA injection into the tongue with continuous i.t. administration of PD98059 or saline. n = 3 in each group. Error bars indicate SEM.

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Journal of Neuroinflammation

ISSN: 1742-2094