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Table 1 Effects of FcγR−/− on α-SYN-induced pro-inflammatory molecules

From: The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia

Fold

4 h

24 h

WT vehicle

WT α-SYN

FcγR−/−vehicle

FcγR−/−α-SYN

WT vehicle

WT α-SYN

FcγR−/−vehicle

FcγR−/−α-SYN

IL-1α

1.00±0.48

3.32±2.45

1.00±0.21

0.55±0.22

1.00±0.17

1.05±0.23

1.00±0.20

1.03±0.42

IP-10

1.00±0.21

5.29±2.93

1.00±0.41

0.79±0.38

1.00±0.23

1.01±0.34

1.00±0.07

1.79±0.42

MIP-1α

1.00±0.21

3.35±0.61a

1.00±0.11

0.97±0.39

1.00±0.09

1.29±0.35

1.00±0.31

2.07±0.93

MIP-1β

1.00±0.23

4.54±0.56a

1.00±0.15

1.19±0.45

1.00±0.08

1.26±0.38

1.00±0.46

2.91±1.55

MIP-2

 

nd

 

1.00±0.20

1.37±0.21

1.00±0.46

1.40±0.75

MCP-1

 

nd

 

1.00±0.12

1.24±0.37

1.00±0.31

1.88±1.10

  1. Conditioned media were collected 4 h and 24 h after the treatment of vehicle or aggregated human α-SYN on WT and FcγR−/− microglia for a 25-plex mouse cytokine/chemokine assay. At 4 h, MIP-1α and MIP-1β were significantly increased with α-SYN treatment in WT microglia but not FcγR−/− microglia compared with vehicle-treated ones. All cytokine and chemokine expression levels were normalized to the level of vehicle-treated WT or FcγR−/− microglia, respectively.
  2. a P <0.001 WT α-SYN vs. WT vehicle. ANOVA with Tukey’s multiple comparison test. nd, not detectable.
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Journal of Neuroinflammation

ISSN: 1742-2094