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Figure 10 | Journal of Neuroinflammation

Figure 10

From: Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells

Figure 10

11β - HSD1 mRNA expression is enhanced by both MR and GR activation . BV-2 cells were treated for 24 h with corticosterone (A), aldosterone (B), or dexamethasone (C) in the presence or absence of 1 μM spironolactone (A, B) or 1 μM RU-486 (A, C). 11β-HSD1 mRNA was quantitated by real-time RT-PCR. Data (mean ± SD from three independent experiments) represent ratios of 11β-HSD1 mRNA to GAPDH control mRNA from treated cells normalized to the values obtained from cells incubated with vehicle (DMSO). **P <0.01, ***P <0.005.

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Journal of Neuroinflammation

ISSN: 1742-2094