Figure 3

AP activity and endotoxin-reactive antibodies in MS and control subjects. Plasma of primary progressive MS (PP-MS) patients, relapsing-remitting MS (RR-MS), healthy controls (HC) and other neurological disease (OND) controls were assessed for total AP activity (A), the four AP isoenzymes (B) and endotoxin levels (C). PP-MS patients showed a decreased level of endotoxin-specific IgM (D; * P <0.05, Bonferroni-corrected Mann–Whitney U test). AP, alkaline phosphatase; IgM, immunoglobulin M; MS, multiple sclerosis.