Endotoxin- and ATP-neutralizing activity of alkaline phosphatase as a strategy to limit neuroinflammation

Table 1 Clinical characteristics of patients and controls

	HC	MS	OND
	(number = 18)	(number = 26)	(number = 11)
Age at onset (SD)	NA	37 (12)	NA
Age at sampling (SD; range)	37 (12; 21 to 59)	Total MS: 41 (12; 19 to 59)	39 (13; 20 to 57)
		RR-MS: 34 (11; 19 to 59)
		PP-MS: 46 (9; 31 to 58)
Female (%)	78	73	45
Disease duration, years (SD)	NA	3 (1)^a	NA
Presenting symptoms (number)
Optic nerve		2
Spinal cord	NA	16	NA
Brainstem/cerebellum		3
Cerebrum		5
Raised IgG-index or oligoclonal bands (number)	NA	18/23	NA

^aAt sampling, five patients were still clinically isolated syndrome (CIS) patients. Of these patients, four developed RR-MS after sampling. One CIS patient was at high risk for developing MS (fulfilment of the Barkhof criteria on MRI and oligoclonal bands and raised IgG-index in the CSF) and was followed for seven years without new neurological complaints. CSF, cerebrospinal fluid; HC, healthy controls; IgG, immunoglobulin G; MRI, magnetic resonance imaging; MS, multiple sclerosis; OND, other neurological disease; PP-MS, primary progressive MS; RR-MS, relapsing-remitting MS; SD, standard deviation.

ISSN: 1742-2094