Sevoflurane reduces CD4+ T cells in the cerebellum of experimental autoimmune encephalomyelitis (EAE) mice. Representative sagittal sections from (A) oxygen-treated and (B) sevoflurane-treated mice were stained with antibody against the CD4 receptor to detect infiltrating T cells, which are visible as small cells staining throughout the white matter. (C) The total numbers of CD4+ cells per field of view were quantified. Data are mean ± SEM of n = 5 sections per animal, three mice per group; *P <0.05 versus oxygen. Scale bar is 500 μm.