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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Susceptibility of juvenile and adult blood–brain barrier to endothelin-1: regulation of P-glycoprotein and breast cancer resistance protein expression and transport activity

Figure 2

Expression of P-glycoprotein in freshly isolated rat brain microvessels after endothelin-1 treatment of juvenile and adult rats. Rats equivalent to pediatric (P21) and adult (P84) human brain were used. Twenty-four hours after intracerebroventricular (icv) injection of endothelin-1 (ET-1) was used to trigger inflammatory reactions, brain microvessels were isolated, and P-glycoprotein expression was assessed by western blot as reported in Methods. Results show no difference in P-glycoprotein expression after ET-1 treatment. Immunoblot represents mean ± S.E.M from three batches of brain endothelial microvessels. Statistical comparisons: *P <0.05, **P <0.01 and ***P <0.0001.

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Journal of Neuroinflammation

ISSN: 1742-2094