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Table 1 Digoxin and prazosin unbound protein fraction in plasma (f u,plasma ) and brain tissue (f u,brain )

From: Susceptibility of juvenile and adult blood–brain barrier to endothelin-1: regulation of P-glycoprotein and breast cancer resistance protein expression and transport activity

Compounds fu,plasma fu,brain fu,brain/fu,plasmaratio
 Prazosin 0.204 ± 0.001 0.071 ± 0.004 0.349
 Digoxin 0.379 ± 0.001 0.218 ± 0.027 0.576