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Table 1 Summary of experimental groups

From: Regulation of enhanced cerebrovascular expression of proinflammatory mediators in experimental subarachnoid hemorrhage via the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway

Experimental group N Time after SAH
   2 min 1 h 6 h 12 h 24 h 36 h 48 h 72 h 96 h
Immunohistochemistry: temporal profile of proinflammatory mediators, pERK1/2 and effect of U0126
0 h (2 min SAH) 3 X         
1 h SAH 3   X        
6 h SAH 3    X       
12 h SAH 3     X      
24 h SAH 3      X     
48 h sham 6        X   
48 h SAH + vehicle 5    V V V V X   
48 h SAH + U0126 6    U U U U X   
72 h sham 5         X  
72 h SAH + vehicle 6    V V V    X  
72 h SAH + U0126 6    U U U    X  
96 h sham 7          X
96 h SAH 6          X
Western blots: ERK activation at early timepoints after SAH
1 h sham 3   X        
1 h SAH 3   X        
6 h sham 3    X       
6 h SAH 3    X       
24 h sham 3      X     
24 h SAH + vehicle 3    V V X     
24 h SAH + U0126 3    U U X     
  1. X indicates termination of all rats in each group. V indicates treatment with vehicle (0.01% dimethylsulfoxide) and U indicates treatment with U0126.
  2. ERK = extracellular signal-regulated kinase; N = no.of rats in each group; SAH = subarachnoid hemorrhage.