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Figure 2 | Journal of Neuroinflammation

Figure 2

From: L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

Figure 2

The increase in the concentration of L-Glu remaining was mainly caused by the downregulation of GLAST. (A) The effects of TBOA (30 to 300 μM), UCPH-101 (0.1 to 10 μM), and DHK (30 to 300 μM) on L-Glu clearance. Concentration-dependent inhibition was obtained by treatment with TBOA and UCPH-101. **P < 0.01 vs. the control group (n = 6), Tukey’s test following ANOVA. (B) The basal expression levels of astrocyte L-Glu transporters and the effect of LPS on their expression levels. Basally, the GLAST protein level is much higher than that of GLT1. The GLAST protein levels significantly decreased after the LPS treatment (10 ng/mL, 72 h), but GLT-1 protein levels did not change. *P < 0.05 vs. the control group (n = 4), Student’s t-test.

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Journal of Neuroinflammation

ISSN: 1742-2094