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Figure 5 | Journal of Neuroinflammation

Figure 5

From: L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

Figure 5

ATP did not contribute to the downregulation of GLAST in the inflammation without cell death. (A, B) Neither ATP nor the P2X7 agonist BzATP affected L-Glu uptake. (C, D) Neither the P2X receptor antagonist TNP-ATP nor the P2X7 specific antagonist BBG affected the LPS-induced decrease in L-Glu uptake. **P < 0.01 vs. control group (n = 6), Tukey’s test following ANOVA.

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Journal of Neuroinflammation

ISSN: 1742-2094