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Figure 8 | Journal of Neuroinflammation

Figure 8

From: L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

Figure 8

The elevation of intracellular L-Glu in astrocytes is important for the downregulation of GLAST. (A, B) The effects of mGluR agonists on L-Glu uptake. Neither the group I mGluR agonist DHPG (A) nor the group II mGluR agonist DCG-4 (B) affected L-Glu uptake. (C) The amount of astrocytic intracellular L-Glu after LPS-treatment in the absence or presence of TBOA in astrocyte-microglia co-cultures. LPS significantly increased the amount of astrocytic intracellular L-Glu, and TBOA completely suppressed this increase. **P < 0.01 vs. control group, ##P < 0.01 vs. the LPS-treated group (n = 6), Tukey’s test following ANOVA. (D) The astrocytic expression of GLAST after LPS treatment in the absence or presence of TBOA in astrocyte-microglia co-cultures. TBOA suppressed the downregulation GLAST caused by LPS. *P < 0.05 vs. control group, #P < 0.05 vs. the LPS-treated group (n = 6), Tukey’s test following ANOVA

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