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Figure 9 | Journal of Neuroinflammation

Figure 9

From: L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

Figure 9

Schematic model of the ‘collusion’ hypothesis for the elevation of extracellular L-Glu in the early stages of inflammation.1. Activated microglia release L-Glu. 2. The resultant elevation of extracellular L-Glu causes the elevation of astrocytic intracellular L-Glu. 3. The elevation of astrocytic intracellular L-Glu downregulates GLAST expression. 4. The decrease in GLAST expression further exacerbates the elevation of extracellular L-Glu

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Journal of Neuroinflammation

ISSN: 1742-2094