(A) Dextran sulphate sodium (DSS)-exposed (4%) mice were treated daily with 0.8 mg/kg or 4 mg/kg pentamidine given intraperitoneally. Effect of pentamidine on (B) DAI score, (C) colonic length and (D) spleen weight in DSS-treated mice. Results are expressed as mean ± SEM of n = 5 experiments. ***P <0.001 vs. vehicle (saline); °P <0.05; °°P <0.01 and °°°P <0.001 vs. DSS. DAI, disease activity index.