Effect of pentamidine on the release of inflammatory mediators (NO
, IL-1β, TNF-α) and S100B in plasma of DSS-treated mice. Results are expressed as mean ± SEM of n = 5 experiments performed in triplicate. ***P <0.001 vs. vehicle (saline); °°P <0.01 and °°°P <0.001 vs. DSS. DSS, dextran sodium sulphate; IL-1β, interleukin-1 beta; NO, nitric oxide; PGE2, prostaglandin E2; TNF-α, tumor necrosis factor alpha.