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Table 1 Cytokine/Chemokine Profiles in F344 and HIV-1Tg Rat Serum

From: Endotoxin-induced cytokine and chemokine expression in the HIV-1 transgenic rat

Cytokines and Chemokines in the Serum with LPS Treatment

 

Protein (pg/ml, ± SD)

F344

IL-1β

KC/GRO

IL-4

IL-5

TNF-α

IFN-γ

IL-13

 

Interleukin 1 beta

 

Interleukin 4

Interleukin 5

Tumor necrosis factor - alpha

Interferon gamma

Interleukin 13

SS+S

83.0(± 21.3)

1294.8(± 589.7)

9.5(± 0.6)

116.0(± 23.7)

42.7(± 6.1)

35.2(± 7.2)

27.5(± 1.1)

SS+L

272.1(± 145.1)

7153.2(± 2779.8)**

15.5(± 1.7)***

348.7(± 202.4)

7531.8(± 7897.0)

138.6(± 46.2)**

42.3(± 9.5)**

LL+S

80.4(± 42.4)

780.9(± 846.6)

10.3(± 51.2)

103.6(± 32.6)

51.2(± 12.4)

56.5(± 19.6)

22.5(± 1.1)

LL+L

125.1(± 23.5)

3293.5(± 680.6)*

11.1(± 1.1)^^

210.0(± 56.7)

88.2(± 25.5)

61.8(± 18.9)^^

26.5(± 2.1)^

HIV - 1Tg

IL-1β

KC/GRO

IL-4

IL-5

TNF-α

IFN-γ

IL-13

 

Interleukin 1 beta

 

Interleukin 4

Interleukin 5

Tumor necrosis factor - alpha

Interferon gamma

Interleukin 13

SS+S

85.2(± 31.6)

1907.4(± 978.9)

10.7(± 2.0)

154.7(± 83.6)

45.2(± 11.4)

67.8(± 32.2)

26.8(± 0.5)

SS+L

307.4(± 72.9)***

7002.2(± 361.0)***

14.4(± 2.5)

258.3(± 37.3)

2366.7(± 924.4)***

122.3(± 13.4)*

36.2(± 6.6)*

LL+S

47.9(± 7.4)

327.6(± 110.5)

8.0(± 1.4)

29.7(± 34.3)

42.8(± 7.0)

18.3(± 24.9)

22.3(± 1.1)

LL+L

128.6(± 3.0)^^^

3051.3(± 1215.7)^^^

11.3(± 0.8)^^

189.1(± 121.1)

113.4(± 51.8)^^^

71.1(± 9.1)^

27.9(± 4.2)^

  1. * P < 0.05, ** P < 0.01, *** P < 0.001 greater than SS+S control; ^ P < 0.05, ^^ P < 0.01, ^^^ P < 0.001 less than SS+L; statistically significant changes are bolded