Effect of INO-1001 treatment on forelimb dexterity. Rats were subjected to TBI or sham surgery, and were treated with INO-1001 or vehicle for 12 days beginning 1 day after surgery. Behavioral assessments were made 8 weeks after TBI. (A) Time to remove an adhesive tape from the contralateal forelimb was markedly increased by TBI, and this time was reduced in the animals treated with INO-1001. n = 6-9; *P < 0.05. (B) Scoring of vermicelli test results. n = 6-9. *P < 0.05, P **P < 0.01, #P < 0.05 vs. sham, vehicle-treated.