Skip to main content
Figure 1 | Journal of Neuroinflammation

Figure 1

From: CCL2 upregulation triggers hypoxic preconditioning-induced protection from stroke

Figure 1

Unique temporal profiles of hypoxic preconditioning induced upregulation of CCL2 message and protein in brain. HPC (4 h, 8%O2) induces an early (A) 11-fold increase in cortical CCL2 mRNA and (B) 1.5-fold increase in CCL2 protein in cortical whole cell lysates, as well as a delayed (C) 3.5-fold increase in CCL2 mRNA expression in cortical endothelial cells (black bars) relative to naïve animals. CCR2 message and protein (grey bars) did not significantly change relative to naïve expression in cortical homogenates (A, B), but did in endothelial homogenates (C) within the same animals at 24 h after HPC. *p < 0.05 vs. respective expression level in naïves.

Back to article page