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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease

Figure 3

Changes in TH-ir in the substantia nigra and striatum in AT1a-null mice. TH-ir at central levels of the (A, C, E) substantia nigra and (B, D, F) striatum in AT1a-null mice (AT1a-/-) injected with vehicle (controls; A, B), with MPTP alone (C, D), or with MPTP + the PPAR-γ antagonist GW9662 (E, F). The number of TH-ir cells in the nigra and TH-ir terminals in the striatum (that is, spared dopaminergic neurons and terminals) was higher in the untreated group (C, D) than in mice treated with GW9662 (E, F). Scale bar: 250 μm (A, C, E) and 560 μm (B, D, F).

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