Figure 6

Activated microglial cells in the SNc. Density of GSI-B4-positive cells one week after treatment with (A) vehicle, telmisartan alone, GW9662 alone, telmisartan + GW9662, MPTP alone, MPTP + telmisartan, or MPTP + telmisartan + GW9662 in WT mice, and (B) vehicle, GW9662 alone, MPTP alone, or MPTP + GW9662 in AT1a-null mice (AT1a^-/-). The microglial cells were quantified as the number of cells per mm³, and the data are presented as mean ± SEM. *P < 0.05 compared with WT mice (A) or AT1a-null mice (B) treated with vehicle, ^# P < 0.05 compared with WT mice (A) or AT1a-null mice (B) treated with MPTP alone, ^Ф P < 0.05 compared with WT mice treated with MPTP + telmisartan (A) or AT1a-null mice (B) treated with MPTP + GW9662, ^δ P < 0.05 compared with WT mice treated with MPTP + telmisartan + GW9662 (one-way ANOVA and Student-Newman-Keuls post-hoc test).