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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Microglial TIR-domain-containing adapter-inducing interferon-β (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-κB

Figure 6

TIR-domain-containing adapter-inducing interferon-&#946 (TRIF) deficiency attenuates inflammation via TANK-binding kinase (TBK)1/I&#954B kinase (IKK)&#949 and nuclear factor (NF)-&#954B signaling. Western blot results for wild-type (WT) and trif-/- microglia pre-stimulated by injured retinal ganglion cells (RGCs) in a transwell system identifies the signaling changes downstream of TRIF. (A) Bar graph showing that TBK1 was upregulated gradually in the WT group; however, trif-/- effectively suppressed TBK1 from 24 to 36 hours. (B) Trif-/- effectively suppressed NF-&#954B from 12 to 36 hours. (C) Bar graph showing that trif-/- effectively suppressed IKK&#949 from 12 to 36 hours. *P <0.05, **P <0.01 vs. WT group at the same time point. &#946-Actin was used as an internal control.

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