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Table 2 Summary of conventional immune workup results in ASD/SPAD children

From: Immunological characterization and transcription profiling of peripheral blood (PB) monocytes in children with autism spectrum disorders (ASD) and specific polysaccharide antibody deficiency (SPAD): case study

Case# IgG1 (mg/dL) IgA (mg/dL) IgM (mg/dL) Pneumococcal antibody titers2 N > 11/14 Isotype-switched memory B cells (cells/μl)3
N = 39.9 (27.1-97.6) 4
Total memory B cells (cells/μl)
N = 77.5 (55.1-198) 4
#1 545 23 96 0/14 7.6 19.6
#2 844 116 190 0/14 8.3 13.2
#3 680 35 23 0/14 6.1 15.1
#4 767 34 59 1/14 5.4 25.0
#5 578 121 136 0/14 2.7 2.9
#6 783 40 107 0/14 21.9 31.0
#7 700 38 29 2/14 8.0 40.8
#8 442 44 66 2/14 1.9 19.0
  1. 1 Normal ranges of Ig levels (mg/dl) are for children of 6-8 yr (IgG; 572-1374, IgM; 30-208, IgA; 34-305) for children of 9-11 yr (IgG; 586-1496, IgM; 48-228, IgA; 45-305) and for children of 12-16 yr (IgG 759-1549, IgM; 35-239, IgA; 58-358).
  2. 2 Numbers of serotypes revealed > 1.0 μg/ml Ab levels among Streptococcus pneumonia 14 serotypes tested. Children > 5 yr is expected to reveal protective levels of Ab titers > 75% of 14 serotype.
  3. 3 Isotype switched memory B cell numbers identified as IgD-, CD27+, CD19+ cells and total memory B cell numbers (CD27+, CD19+ cells) were expressed as cell numbers/μl of peripheral blood.
  4. 4 Reference values of these parameters obtained from 27 normal controls (Age; 2-17 yr) in our laboratory are shown as a median (range).