Immunological characterization and transcription profiling of peripheral blood (PB) monocytes in children with autism spectrum disorders (ASD) and specific polysaccharide antibody deficiency (SPAD): case study

Table 2 Summary of conventional immune workup results in ASD/SPAD children

Case#	IgG¹ (mg/dL)	IgA (mg/dL)	IgM (mg/dL)	Pneumococcal antibody titers² *N > 11/14*	Isotype-switched memory B cells (cells/μl)³ N = *39.9 (27.1-97.6)* ⁴	Total memory B cells (cells/μl) N = *77.5 (55.1-198)* ⁴
#1	545	23	96	0/14	7.6	19.6
#2	844	116	190	0/14	8.3	13.2
#3	680	35	23	0/14	6.1	15.1
#4	767	34	59	1/14	5.4	25.0
#5	578	121	136	0/14	2.7	2.9
#6	783	40	107	0/14	21.9	31.0
#7	700	38	29	2/14	8.0	40.8
#8	442	44	66	2/14	1.9	19.0

¹ Normal ranges of Ig levels (mg/dl) are for children of 6-8 yr (IgG; 572-1374, IgM; 30-208, IgA; 34-305) for children of 9-11 yr (IgG; 586-1496, IgM; 48-228, IgA; 45-305) and for children of 12-16 yr (IgG 759-1549, IgM; 35-239, IgA; 58-358).
² Numbers of serotypes revealed > 1.0 μg/ml Ab levels among Streptococcus pneumonia 14 serotypes tested. Children > 5 yr is expected to reveal protective levels of Ab titers > 75% of 14 serotype.
³ Isotype switched memory B cell numbers identified as IgD^-, CD27⁺, CD19⁺ cells and total memory B cell numbers (CD27⁺, CD19⁺ cells) were expressed as cell numbers/μl of peripheral blood.
⁴ Reference values of these parameters obtained from 27 normal controls (Age; 2-17 yr) in our laboratory are shown as a median (range).

ISSN: 1742-2094