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Figure 4 | Journal of Neuroinflammation

Figure 4

From: CD4+ CD25+ FoxP3+ regulatory T cells suppress cytotoxicity of CD8+ effector T cells: implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level

Figure 4

OT-II regulatory T (T reg) cells reduce release of cytotoxic effector molecules from OT-I T cells in acute brain slices form ODC-OVA mice. Representative flow cytometry analysis of activation markers (CD25, left panel) and intracellular effector molecules (granzyme B, right panel) of OT-I T cells retrieved and pooled from ODC-OVA slices incubated with activated OT-I T cells alone or together with OT-II T reg cells. Mean fluorescence intensities (MFI) of pooled OT-I T cells from slices incubated in the absence and presence of OT-II T reg cells were 455 vs 478 for CD25 (left panel) and 63 vs 79 for intracellular granzyme B (right panel).

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Journal of Neuroinflammation

ISSN: 1742-2094