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Figure 3 | Journal of Neuroinflammation

Figure 3

From: The cytokine tumor necrosis factor-like weak inducer of apoptosis and its receptor fibroblast growth factor-inducible 14 have a neuroprotective effect in the central nervous system

Figure 3

Treatment with TWEAK induces ischemic tolerance in vivo. Wt and Fn14-/- mice treated with vehicle (control; black bars) or TWEAK 0.2 mg by intraperitoneal injection (gray bars) 24 hours before tMCAO. The volume of the ischemic lesion was quantified in Wt mice 24 and 48 hours later. *P < 0.05 compared to non-preconditioned Wt mice. n = 10 per experimental group. Lines denote SD. Fn14: fibroblast growth factor-inducible 14; Ns: non-significant; tMCAO: transient middle cerebral artery occlusion; TTC: triphenyltetrazolium chloride; TWEAK: tumor necrosis factor-like weak inducer of apoptosis; Wt: wild-type.

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