Treatment with TWEAK induces ischemic tolerance
in vivo. Wt and Fn14-/- mice treated with vehicle (control; black bars) or TWEAK 0.2 mg by intraperitoneal injection (gray bars) 24 hours before tMCAO. The volume of the ischemic lesion was quantified in Wt mice 24 and 48 hours later. *P < 0.05 compared to non-preconditioned Wt mice. n = 10 per experimental group. Lines denote SD. Fn14: fibroblast growth factor-inducible 14; Ns: non-significant; tMCAO: transient middle cerebral artery occlusion; TTC: triphenyltetrazolium chloride; TWEAK: tumor necrosis factor-like weak inducer of apoptosis; Wt: wild-type.