Figure 3

Declined neurologic deficits and inflammation in MyD88 ^−/− and TRIF ^−/− mice. Compared to WT mice, both MyD88^−/− and TRIF^−/− mice had decreased brain water content (A), NDS (B), (C) Both MyD88^−/− and TRIF^−/− mice showed decreased protein levels of IL-6, TNF-α, and IL-1β, and (D) immunohistochemistry of CD68 showed decreased macrophage infiltration in the perihematoma region of MyD88^−/− and TRIF^−/− brain on day3 post-ICH. **P < 0.01 vs. sham group; ^## P < 0. 01 vs. WT group. ^$$ P < 0.01 vs. WT group, Bar = 50 μM in D. Values (mean ± SD, n = 3 for each group) are representative of three independent experiments.