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Figure 10 | Journal of Neuroinflammation

Figure 10

From: Inflammatory monocytes damage the hippocampus during acute picornavirus infection of the brain

Figure 10

Immunodepletion of inflammatory monocytes preserves cognitive function in the Morris water maze. Uninfected mice, untreated Theiler's murine encephalomyelitis virus (TMEV)-infected mice (No Tx), and infected mice treated with RB6-8C5 to deplete inflammatory monocytes and neutrophils (RB6 Tx) were assessed in the Morris water maze starting at 14 dpi. Following 3 days of training on a visible platform, latency to hidden platform acquisition was measured over six trials each day for 6 days. Pretesting latency to the hidden platform is shown (PRE) and compared to the latency to acquisition during the sixth and final trial of each day (DAY1 to DAY6). The uninfected mice readily learned the maze and navigated to the escape platform in less than 10 s by day 5. RB6-8C5 immunodepleted mice performed as well as uninfected controls. In contrast, the infected mice that were not depleted were unable to learn the maze at any point during the testing phase. These observations are consistent with the hippocampal pathology findings in Figure 9. Results are from 10 mice in each group.

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